Ep 27. Can a single vaccine (BCG) on the first day of life protect against many unrelated infections? Expert Guests: Professor Tobias Kollmann and Assistant Professor Nelly Amenyogbe

 “Can a single vaccine (BCG) on the first day of life protect against many unrelated infections?” Expert Guests: Professor Tobias Kollmann and Assistant Professor Nelly Amenyogbe

What about if you could give your baby a vaccine on day 1 of life and it would protect against many infections. This sounds almost like a miracle or fantasy that a single vaccine could protect against many unrelated infections. This episode looks at the BCG vaccine and how it offers young babies more than just protection against tuberculosis. This episode will transform your understanding of how vaccines work, the potential for future developments, and a tiny intro into why your baby's immunity is so special. Experts have been slow to embrace this phenomenon of the broad effects of vaccines because of dogma about how the immune system works. Some other scientists have criticised the evidence as being too weak.  But things are changing and we are thrilled to discuss it with our guests who not only will help share some of the history on how the knowledge of this came about but what their work has done for the field in pushing forward our understanding on the baby’s immune system and how this vaccine effect might work. 

Dr Eliz Kilich, with co‑host Dr Lydia Yarlott, are joined today by Professor Tobias Kollmann and Assistant Professor Nelly Amenyogbe to explore this topic and what it means to get the BCG vaccine on day 1 of life.  Prof. Kollmann completed his MD and PhD at the Albert of Einstein College of Medicine, Bronx NY, followed by a residency in pediatrics and fellowship in infectious diseases at the University of Washington, Seattle, WA with Prof. Chris Wilson. He then served as Division Head for Pediatric Infectious Diseases at the University of British Columbia, BC Children’s Hospital before taking on the Director’s position of Systems Vaccinology at Telethon Kids Institute in Perth, Australia. He currently is Prof. of Microbiology & Immunology as well as Pediatric Infectious Diseases at Dalhousie University in Halifax, NS, Canada. Tobi is the CEO of the Born Strong Initiative (https://www.born-strong.org/), a global network of experts working to reduce adverse pregnancy outcomes. His expertise centers around immune ontogeny as well as maternal and early life vaccine responses employing cutting edge technology and analytics to extract the most information out of the small biological samples obtainable.

 Dr Nelly Amenyogbe, is Assistant Professor Department of Microbiology & Immunology, Dalhousie University, Halifax, Canada. Her previous research showed how BCG, the vaccine against tuberculosis, reduces risk to die from newborn sepsis within days of being given. Current projects build on these initial observations to identify how host metabolism influences the immune response to infection, especially colostrum feeding for newborns, which may influence the efficacy of immune-targeting therapies. These research questions are answered using preclinical models, and multi-omics surveys of human maternal and neonatal immune responses.

Further Reading:

- The Scientist: How some vaccines protect more than against their target